2025 NFL Picks – Week 12: Panthers at 49ers

2025 NFL Picks – Week 12: Other Games

NFL Picks Week 12 – Early Games

Bills at Texans  |  Steelers at Bears  |  Patriots at Bengals  |  Giants at Lions  |  Vikings at Packers  |  Seahawks at Titans  |  Colts at Chiefs  |  Jets at Ravens  | 

NFL Picks Week 12 – Late Games

Browns at Raiders  |  Jaguars at Cardinals  |  Eagles at Cowboys  |  Falcons at Saints  |  Buccaneers at Rams  |  Panthers at 49ers  | 


Carolina Panthers (6-5) at San Francisco 49ers (7-4)
Line: 49ers by 6.5. Total: 48.

Tuesday, Nov. 25, 8:15 PM

The Matchup. Edge: .


The Motivation. Edge: .


The Spread. Edge: .

WalterFootball.com Calculated Spread: .

Westgate Advance Point Spread: 49ers -6.5.

Computer Model: .


The Vegas. Edge: .

Percentage of money on TEAM: X% (Y bets)


The Trends. Edge: .

  • 49ers are 44-33 ATS as favorites in night games since 1989.
  • Opening Line: 49ers -6.
  • Opening Total: 45.5.
  • Weather: .




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    2025 NFL Picks – Week 12: Other Games



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