2025 NFL Picks – Week 12: Jaguars at Cardinals

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NFL Picks Week 12 – Early Games

Bills at Texans  |  Steelers at Bears  |  Patriots at Bengals  |  Giants at Lions  |  Vikings at Packers  |  Seahawks at Titans  |  Colts at Chiefs  |  Jets at Ravens  | 

NFL Picks Week 12 – Late Games

Browns at Raiders  |  Jaguars at Cardinals  |  Eagles at Cowboys  |  Falcons at Saints  |  Buccaneers at Rams  |  Panthers at 49ers  | 


Jacksonville Jaguars (6-4) at Arizona Cardinals (3-7)
Line: Jaguars by 2.5. Total: 47.5.

Sunday, Nov. 23, 4:05 PM

The Matchup. Edge: .


The Motivation. Edge: .


The Spread. Edge: .

WalterFootball.com Calculated Spread: .

Westgate Advance Point Spread: Cardinals -1.5.

Computer Model: .


The Vegas. Edge: .

Percentage of money on TEAM: X% (Y bets)


The Trends. Edge: .

  • Jaguars are 69-116 ATS against non-divisional opponents since 2008.
  • Jaguars are 23-56 ATS vs. NFC opponents since 2007.
  • Cardinals are 52-34 ATS at home as underdogs or favorites of less than -3 since 2007.
  • Opening Line: Jaguars -2.5.
  • Opening Total: 47.5.
  • Weather: .




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