NFL Picks Against the Spread: Week 5, 2025 – Late Games

Patrick Mahomes
2024 NFL Picks: 0-0 ($0)

NFL Picks (2023): 143-141-10 (-$6,860)
NFL Picks (2022): 154-134-8 (+$9,860)
NFL Picks (2021): 144-137-2 (-$5,365)
NFL Picks (2020): 138-124-7 (+$9,350)
NFL Picks (2019): 148-128-9 (+$1,200)
NFL Picks (2018): 140-134-12 (+$845)
NFL Picks (2017): 137-147-10 (-$4,300)
NFL Picks (2016): 148-127-10 (+$780)
NFL Picks (2015): 133-138-10 (-$3,215)
NFL Picks (2014): 143-133-7 (-$1,885)
NFL Picks (2013): 144-131-8 (+$7,825)
NFL Picks (2012): 130-145-8 (-$7,445)
NFL Picks (2011): 137-133-12 (-$1,335)
NFL Picks (2010): 144-131-8 (+$5,880)
NFL Picks (2009): 151-124-9 (+$4,235)
NFL Picks (2008): 136-125-6 (+$6,105)
NFL Picks (2007): 162-135-10 (+$3,585)
If you don’t quite understand the line, total or anything else, go to my Sports Betting FAQ.

Vegas betting action updated Oct. X, 2:00 p.m. ET. Follow @walterfootball for updates.


Go to Week 5 NFL Picks – Early Games




Individual Game Pages

NFL Picks Against the Spread: Week 5 Late Games


Tennessee Titans (0-4) at Arizona Cardinals (2-2)
Line: Cardinals by 9.5. Total: 40.5.

Sunday, Oct. 5, 4:05 PM

The Matchup. Edge: .


The Motivation. Edge: .


The Spread. Edge: .

WalterFootball.com Calculated Spread: .

Westgate Advance Point Spread: Cardinals -8.

Computer Model: .


The Vegas. Edge: None.

Percentage of money on TEAM: X% (Y bets)


The Trends. Edge: Titans.

  • Cardinals are 6-16 ATS as favorites of 7.5 or more the previous 22 instances.
  • Opening Line: Cardinals -8.
  • Opening Total: 41.5.
  • Weather: .




  • Week 5 NFL Pick:



    Tampa Bay Buccaneers (3-1) at Seattle Seahawks (3-1)
    Line: Seahawks by 3. Total: 44.5.

    Sunday, Oct. 5, 4:05 PM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Seahawks -1.5.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: None.

  • Road Team is 146-100 ATS in Buccaneers games since 2009.
  • Seahawks are 61-48 ATS as home favorites since 2007.
  • Seahawks are 22-12 ATS as home underdogs since 2009.
  • Opening Line: Seahawks -1.5.
  • Opening Total: 44.5.
  • Weather: .




  • Week 5 NFL Pick:



    Detroit Lions (3-1) at Cincinnati Bengals (2-1*)
    Line: Lions by 8.5. Total: 49.

    Sunday, Oct. 5, 4:25 PM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Lions -7.5.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: None.

  • Opening Line: Lions -7.5.
  • Opening Total: 48.5.
  • Weather: .




  • Week 5 NFL Pick:



    Washington Redskins (2-2) at Los Angeles Chargers (3-1)
    Line: Chargers by 2.5. Total: 47.5.

    Sunday, Oct. 5, 4:25 PM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Chargers -3.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: Chargers.

  • Jim Harbaugh is 12-4 ATS after a loss, excluding 2014.
  • Opening Line: Chargers -2.5.
  • Opening Total: 47.5.
  • Weather: .




  • Week 5 NFL Pick:



    New England Patriots (2-2) at Buffalo Bills (4-0)
    Line: Bills by 8.5. Total: 49.5.

    Sunday, Oct. 5, 8:20 PM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Bills -10.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: Bills.

  • History: Bills have won 8 of the last 9 meetings, excluding when they sat their starters.
  • Opening Line: Bills -10.5.
  • Opening Total: 49.5.
  • Weather: .




  • Week 5 NFL Pick:



    Kansas City Chiefs (2-2) at Jacksonville Jaguars (3-1)
    Line: Chiefs by 3. Total: 45.5.

    Monday, Oct. 6, 8:15 PM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Chiefs -3.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: Chiefs.

  • Patrick Mahomes is 102-27 SU, 68-59 ATS (54-45 ATS when not favored by double digits.)
  • Jaguars are 67-113 ATS against non-divisional opponents since 2008.
  • Opening Line: Chiefs -3.
  • Opening Total: 45.5.
  • Weather: .




  • Week 5 NFL Pick:




    Prop/Teaser/Parlay Picks
    A list of some of my favorite team/player prop picks this week
    (Offense & defensive ROY picks to be counted whenever winners are announced.) Picks carried over on a week-to-week basis will be in black.


    NFL Picks Week 5 – Early Games

    Individual Game Pages




    Comments on the 2025 NFL Season’s Games and Picks


    NFL Picks - Sept. 11


    Fantasy Football Rankings - Sept. 7


    2024 NFL Mock Draft - July 25


    NFL Power Rankings - June 2





    Review Walt’s Past Record Picking Games

    On the bottom half of our NFL Weekly Lander page is the history of picks Walt maintains. Walt’s Results