September 22, 2025
Premium Users get access to ad-free content on Debacled | Check-In.

NFL Picks Against the Spread: Week 4, 2025 – Early Games

Walt011 mins
2024 NFL Picks: 0-0 ($0)

NFL Picks (2023): 143-141-10 (-$6,860)
NFL Picks (2022): 154-134-8 (+$9,860)
NFL Picks (2021): 144-137-2 (-$5,365)
NFL Picks (2020): 138-124-7 (+$9,350)
NFL Picks (2019): 148-128-9 (+$1,200)
NFL Picks (2018): 140-134-12 (+$845)
NFL Picks (2017): 137-147-10 (-$4,300)
NFL Picks (2016): 148-127-10 (+$780)
NFL Picks (2015): 133-138-10 (-$3,215)
NFL Picks (2014): 143-133-7 (-$1,885)
NFL Picks (2013): 144-131-8 (+$7,825)
NFL Picks (2012): 130-145-8 (-$7,445)
NFL Picks (2011): 137-133-12 (-$1,335)
NFL Picks (2010): 144-131-8 (+$5,880)
NFL Picks (2009): 151-124-9 (+$4,235)
NFL Picks (2008): 136-125-6 (+$6,105)
NFL Picks (2007): 162-135-10 (+$3,585)
If you don’t quite understand the line, total or anything else, go to my Sports Betting FAQ.

Vegas betting action updated Sept. X, 2:00 p.m. ET. Follow @walterfootball for updates.


Go to Week 4 NFL Picks – Late Games




Individual Game Pages

Seahawks at Cardinals  |  Vikings at Steelers  |  Eagles at Buccaneers  |  Saints at Bills  |  Panthers at Patriots  |  Redskins at Falcons  |  Browns at Lions  |  Titans at Texans  |  Chargers at Giants  |  Jaguars at 49ers  |  Colts at Rams  |  Bears at Raiders  |  Ravens at Chiefs  |  Packers at Cowboys  |  Jets at Dolphins  |  Bengals at Broncos  | 

NFL Picks Against the Spread: Week 4 Early Games


Seattle Seahawks (2-1) at Arizona Cardinals (2-1)
Line: Cardinals by 1. Total: 43.5.
Thursday, Sept. 25, 8:15 PM

The Matchup. Edge: .


The Motivation. Edge: .


The Spread. Edge: .

WalterFootball.com Calculated Spread: .

Westgate Advance Point Spread: Cardinals -2.5.

Computer Model: .


The Vegas. Edge: None.

Percentage of money on TEAM: X% (Y bets)


The Trends. Edge: None.

  • History: Road team has won 14 of the past 20 meetings, excluding a 2016 tie.
  • Cardinals are 51-34 ATS at home as underdogs or favorites of less than -3 since 2007.
  • Opening Line: Cardinals -2.5.
  • Opening Total: 43.5.
  • Weather: Dome.




    • Week 4 NFL Pick:



    Minnesota Vikings (2-1) at Pittsburgh Steelers (2-1)
    Line: Vikings by 1.5. Total: 41.5.
    Sunday, Sept. 28, 9:30 AM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Steelers -1.5.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: Steelers.

  • Mike Tomlin is 63-36 ATS as an underdog.
  • Aaron Rodgers is 135-100 ATS since 2009.
  • Aaron Rodgers is 31-24 ATS as an underdog.
  • Opening Line: Steelers -1.
  • Opening Total: 40.5.
  • Weather: .




    • Week 4 NFL Pick:



    Philadelphia Eagles (3-0) at Tampa Bay Buccaneers (3-0)
    Line: Eagles by 3. Total: 45.5.
    Sunday, Sept. 28, 1:00 PM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Eagles -2.5.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: Eagles.

  • Road Team is 145-100 ATS in Buccaneers games since 2009.
  • Buccaneers are 45-76 ATS at home in the previous 121 instances.
  • Buccaneers are 14-33 ATS as a home underdog since 2009.
  • Opening Line: Eagles -2.5.
  • Opening Total: 45.5.
  • Weather: .




    • Week 4 NFL Pick:



    New Orleans Saints (0-3) at Buffalo Bills (3-0)
    Line: Bills by 16.5. Total: 48.
    Sunday, Sept. 28, 1:00 PM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Bills -14.5.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: Saints.

  • Bills are 15-38 ATS after playing the Miami Dolphins since 1998.
  • Opening Line: Bills -14.5.
  • Opening Total: 47.5.
  • Weather: .




    • Week 4 NFL Pick:



    Carolina Panthers (1-2) at New England Patriots (1-2)
    Line: Patriots by 4.5. Total: 44.5.
    Sunday, Sept. 28, 1:00 PM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Patriots -5.5.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: None.

  • Opening Line: Patriots -5.5.
  • Opening Total: 43.5.
  • Weather: .




    • Week 4 NFL Pick:



    Washington Redskins (2-1) at Atlanta Falcons (1-2)
    Line: Redskins by 2.5. Total: 45.5.
    Sunday, Sept. 28, 1:00 PM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Redskins -1.5.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: None.

  • Opening Line: Redskins -1.5.
  • Opening Total: 46.
  • Weather: .




    • Week 4 NFL Pick:



    Cleveland Browns (1-2) at Detroit Lions (1-1*)
    Line: Lions by 8.5. Total: 45.5.
    Sunday, Sept. 28, 1:00 PM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Lions -9.5.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: None.

  • Lions are 21-8 ATS after losing by 20+ points since 2007. ???
  • Opening Line: Lions -9.5.
  • Opening Total: 46.5.
  • Weather: .




    • Week 4 NFL Pick:



    Tennessee Titans (0-3) at Houston Texans (0-3)
    Line: Texans by 7. Total: 39.5.
    Sunday, Sept. 28, 1:00 PM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Texans -6.5.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: Texans.

  • History: Texans have won 4 of the last 5 meetings.
  • Texans are 58-45 ATS after two or more consecutive losses (9-11 ATS as favorites).
  • Opening Line: Texans -6.5.
  • Opening Total: 39.5.
  • Weather: .




    • Week 4 NFL Pick:



    Los Angeles Chargers (3-0) at New York Giants (0-3)
    Line: Chargers by 5.5. Total: 45.5.
    Sunday, Sept. 28, 1:00 PM

    The Matchup. Edge: .


    The Motivation. Edge: .


    The Spread. Edge: .

    WalterFootball.com Calculated Spread: .

    Westgate Advance Point Spread: Chargers -5.5.

    Computer Model: .


    The Vegas. Edge: None.

    Percentage of money on TEAM: X% (Y bets)


    The Trends. Edge: None.

  • Jim Harbaugh is 10-1 ATS in 1 p.m. East Coast games.
  • Russell Wilson is 35-18 ATS after a loss since his second season.
  • Russell Wilson is 37-22 ATS as an underdog.
  • Opening Line: Chargers -5.5.
  • Opening Total: 45.5.
  • Weather: .




    • Week 4 NFL Pick:




    Prop/Teaser/Parlay Picks
    A list of some of my favorite team/player prop picks this week
    (Offense & defensive ROY picks to be counted whenever winners are announced.) Picks carried over on a week-to-week basis will be in black.

    NFL Picks Week 4 – Late Games

    Individual Game Pages

    Seahawks at Cardinals  |  Vikings at Steelers  |  Eagles at Buccaneers  |  Saints at Bills  |  Panthers at Patriots  |  Redskins at Falcons  |  Browns at Lions  |  Titans at Texans  |  Chargers at Giants  |  Jaguars at 49ers  |  Colts at Rams  |  Bears at Raiders  |  Ravens at Chiefs  |  Packers at Cowboys  |  Jets at Dolphins  |  Bengals at Broncos  | 


    Comments on the 2025 NFL Season’s Games and Picks


    NFL Picks - Sept. 11


    Fantasy Football Rankings - Sept. 7


    2024 NFL Mock Draft - July 25


    NFL Power Rankings - June 2





    Review Walt’s Past Record Picking Games

    On the bottom half of our NFL Weekly Lander page is the history of picks Walt maintains. Walt’s Results

    Related News