Update (Saturday, 4:57 PM ET): James will be out for at least four games with a hamstring injury, starting with the Texans game next Sunday, according to Aaron Wilson of KPRC 2 Houston.
Update (Saturday, 4:01 PM ET): The Chargers placed S Derwin James Jr. on injured reserve, according to Adam Schefter of ESPN.
Update (Friday, 4:16 PM ET): Derwin James (hamstring) will not play in Week 8 against the Rams, according to Rotoworld.
Chargers S Derwin James had a setback in his return from a hamstring injury and may go on injured reserve, the Chargers' coach said, according to Ian Rapoport of NFL Network. James hasn't played since Sept. 27.