For me, it's all about the best player available (BPA) that fills a need for your team. The only exception is QB because the NFL is a QB driven league and you need one to win it all. There are a few exceptions like when you have a dominating defense like Denver did.
Vince Young, QB, Titans
The Chargers have been poor versus the pass lately; each of the last three quarterbacks to face them has posted 239 yards or more, including Brady Quinn and Carson Palmer.
SD: QB Philip Rivers, RB LaDainian Tomlinson, WR Vincent Jackson, TE Antonio Gates. TEN: RB Chris Johnson.
With a championship or semi-final on the line, you can't trust any of these guys.
Bills at Falcons
Jason Snelling, RB, Falcons
Mike Smith is either dumb or insane, so he may try to push Michael Turner back into the lineup after yet another setback to his high ankle sprain. However, there's a good chance that Jason Snelling starts. If so, he's a good fantasy play; Snelling will be battling a defense that has surrendered at least 100 rushing yards to each foe since Week 3.
ATL: WR Roddy White, TE Tony Gonzalez.
Fred Jackson, RB, Bills
In the past five weeks, the highest rushing total Atlanta allowed was 103 to the Eagles. They completely put the clamps on Thomas Jones on Sunday.
Brian Brohm will start. Who knows what you're going to get with him?
Matt Ryan, QB, Falcons
Matt Ryan is hurt. Plus, Buffalo owns 26 interceptions and has held six consecutive opponents to 210 passing yards or less.
Not a bad start if you don't have any options. Derek Anderson tends to throw a lot of picks.
Michael Bush, RB, Raiders
Who knows how the Raiders plan on running the ball this week? Michael Bush could get anywhere between 4-20 carries.
Jerome Harrison, RB, Browns
Jerome Harrison seemingly has a great matchup. Two things: The Raiders shut down Knowshon Moreno last week. Also, Eric Mangina might go with Chris Jennings this week. He's that much of a douche.
Joe Flacco, QB, Ravens
Only if Troy Polamalu is out again. In his past two games, Joe Flacco is 34-of-49 for 464 yards, five touchdowns and no interceptions.
The Ravens don't get many sacks, but they should be able to generate some against Ben Roethlisberger.
BAL: RB Ray Rice, WR Derrick Mason. PIT: QB Ben Roethlisberger, WR Hines Ward, WR Santonio Holmes, TE Heath Miller, Steelers Defense.
Rashard Mendenhall, RB, Steelers
No team has gained more than 4.1 YPC against the Ravens since Adrian Peterson and the Vikings managed to do so back on Oct. 18. Rashard Mendenhall's not a terrible start because he had 91 rushing yards against Baltimore the last time he played them, but you might have better options.
Chris Wells, RB, Cardinals
Excluding last week because the Texans don't run the ball, the last time the Rams have allowed less than 120 rushing yards to an opponent was Oct. 11. Chris Wells is getting more touches each week.
Two words: Keith Null.
STL: RB Steven Jackson. ARZ: QB Kurt Warner, WR Larry Fitzgerald, WR Anquan Boldin.
Tim Hightower, RB, Cardinals
His carry totals the last three weeks: 6, 2, 6.