One of the best NFL trends that I'm aware of is something called the "Hello, Good Bye."
Sounds silly, but it's 30-5 against the spread since 2002. Yeah... wow. The only downside is that this is available about only five times per year.
Basically, you bet on a favorite of 6.5 points or more a week before their bye. The thought process behind this is that a good team (if they're favored by 6.5+, they must be good) will be extremely focused prior to their week off.
As usual, let's look at a coach-by-coach breakdown: