For me, it's all about the best player available (BPA) that fills a need for your team. The only exception is QB because the NFL is a QB driven league and you need one to win it all. There are a few exceptions like when you have a dominating defense like Denver did.
St. Louis Rams: Jerel Worthy, DT, Michigan State
This is yet another reason why the Rams have to take Justin Blackmon over Fletcher Cox. There will be plenty of defensive tackles available atop Round 2. Devon Still, Kendall Reyes and Jerel Worthy all could be options.
Starting defensive tackles Fred Robbins and Justin Bannan were both released this offseason. The Rams added Kendall Langford through free agency, but he's not enough.
Indianapolis Colts: Coby Fleener, TE, Stanford
When teams draft a quarterback early, they typically like to complement their new signal-caller with some protection or a play-maker. Think Matthew Stafford-Brandon Pettigrew, Sam Bradford-Rodger Saffold, Christian Ponder-Kyle Rudolph, and so on. The cupboard is pretty bare on offense in Indianapolis, so the front office needs to provide Andrew Luck with some help.
So, why not Luck's former teammate? This is a slam dunk if Coby Fleener somehow falls out of Round 1. The Colts really need a tight end with Dallas Clark and Jacob Tamme both gone.
Minnesota Vikings: Alshon Jeffery, WR, South Carolina
The Vikings must continue to build around Christian Ponder, which includes spending a high draft pick on a receiver. Minnesota has nothing at the position outside of Percy Harvin and Jerome Simpson, who was signed to just a 1-year deal. The team has shown a tremendous amount of interest in Alshon Jeffery, who was once a top-15 prospect. He provides great value at No. 35.
By the way, if the Vikings foolishly pass on Matt Kalil, they'll likely go with Mitchell Schwartz at this spot.
Tampa Bay Buccaneers: Doug Martin, RB, Boise State
The recently fired Raheem Morris said it himself - this offense has no explosion. LeGarrette Blount is a great runner, but he doesn't offer much in the pass-catching department.
Doug Martin would be a perfect complement. Drawing comparisons to Ray Rice, Martin excels in receiving and blocking. He'd be a great second-round addition for the Buccaneers.
Cleveland Browns: Mike Adams, OT, Ohio State
Mike Holmgren and Tom Heckert love bolstering the offensive front with early draft picks. Why not complement Trent Richardson with a major upgrade on the right side?
Mike Adams will probably fall into Round 2 because of his positive drug test at the Combine, but Mike Holmgren has taken chances on players in similar situations.
Jacksonville Jaguars: A.J. Jenkins, WR, Illinois
Signing Laurent Robinson wasn't enough. The Jaguars must spend one of their first two picks on a receiver. Otherwise, Gene Smith risks having another terrible year from Blaine Gabbert, which would probably mean that he would be fired.
Pick change; previously Jayron Hosley, CB
St. Louis Rams: Janoris Jenkins, CB, North Alabama
Janoris Jenkins is definitely worth taking a flier on in the second round. He's had major character issues in the past, but seems to have turned his life around. If he truly has, the Rams will be getting a top-15 talent with their second selection on Day 2. Besides, the Titans took chances on shady individuals when Jeff Fisher was coaching them.
Pick change; previously Lamar Miller, RB
Carolina Panthers: Rueben Randle, WR, LSU
The Panthers need to find some weapons for Cam Newton. Even if they truly still like Brandon LaFell, they'll need a future successor for Steve Smith. Besides, Rueben Randle provides some good value here, as some project him as a late first-round pick even though he couldn't get open against Dre Kirkpatrick in two meetings.
Buffalo Bills: Ron Brooks, CB, LSU
Both Buddy Nix and Chan Gailey discussed their need to improve the cornerback position. Ron Brooks could be someone they're interested in at this juncture.
Pick change; previously Brian Quick, WR
Miami Dolphins: Nick Perry, DE, USC
As mentioned back in Round 1, the Dolphins desperately need an upgrade across from Cameron Wake. Nick Perry is a tremendous steal here even though Adam Schefter predicted that he would fall to Round 2. Perry can play both the 4-3 and 3-4, so he'd be a good fit for Joe Philbin's hybrid defense.
Seattle Seahawks: Andre Branch, DE/OLB, Clemson
The Seahawks really struggled to get to the quarterback this past year because Raheem Brock no longer provided any sort of pass rush from the left end position. Brock is no longer with the team anyway, so Seattle will have to find someone to take his spot as a situational pass-rusher. Also keep in mind that Chris Clemons will be a 31-year-old free agent the following offseason.
Pick change; previously Mychal Kendricks, ILB
Kansas City Chiefs: Brandon Weeden, QB, Oklahoma State
E-mailer Greg H. asked me which team I thought had the most talent on the roster outside of the quarterback position. I thought about it, and I came up with the Chiefs. They're pretty much stacked everywhere - except for that all-important signal-caller spot. It wouldn't hurt to add competition for Matt Cassel. I don't consider Brady Quinn competition.
Brandon Weeden makes sense because he's presumably ready to step in right away. The Chiefs can win the Super Bowl with good quarterback play, so they're not interested in someone they can groom for a couple of years.
Dallas Cowboys: Ronnell Lewis, DE/OLB, Oklahoma
Anthony Spencer has been franchised, but that won't keep the Cowboys from spending a Day 2 selection on a rush linebacker. Spencer has severe consistency issues.
Philadelphia Eagles: Devon Still, DT, Penn State
Andy Reid will address the defensive line early in the 2012 NFL Draft. If he doesn't do it at No. 15 overall, he could easily do it here. Reid loves Devon Still, so he wouldn't hesitate to select him under these circumstances.
Pick change; previously Janoris Jenkins, CB
New York Jets: Mohamed Sanu, WR, Rutgers
The Jets need to find some help for Tim Tebow. Chaz Schilens is one of their starting receivers. Chaz Schilens!
Pick change; previously Andre Branch, DE/OLB
New England Patriots: Amini Silatolu, G/OT, Midwestern State
Bill Belichick loves versatile linemen. He's also shown interest in Amini Silatolu, who could go in the bottom of the first round. Silatolu can play both guard positions and right tackle.
Pick change; previously Devon Still, DE/DT
San Diego Chargers: Josh Robinson, CB/KR, Central Florida
It's hard to believe, but Quentin Jammer will be 33 a couple of months after the 2012 NFL Draft. Norv Turner discussed possibly moving Jammer to safety sometime down the road.
Pick change; previously Mohamed Sanu, WR
Chicago Bears: Kevin Zeitler, G, Wisconsin
Mike Tice did a phenomenal job with the offensive line this past year. However, the front still needs some help in the interior. Kevin Zeitler is a great fit for the scheme, and he happens to be one of the top prospects on the board.
Philadelphia Eagles: Bobby Wagner, LB, Utah State
Andy Reid hates drafting linebackers, but he may have to change his strategy after this nightmare of a season. Reid may not be the head coach of the Eagles in 2013 if he misses the playoffs again.
Tennessee Titans: Lavonte David, OLB, Nebraska
Colin McCarthy played really well since taking over for a struggling Barrett Ruud. It looks like he'll be the long-term answer in the middle. Now, the Titans have to find an upgrade on the weak side.
Cincinnati Bengals: David Wilson, RB, Virginia Tech
David Wilson is a steal down here. I had him atop this second round in a previous update, but he just happens to fall out of circumstance - something that happens to various prospects for whatever reasons every year.
The Bengals have a great run-blocking offensive line. It's just a shame that they have nothing in the backfield to speak of. BenJarvus Green-Ellis was signed, but he's nothing more than a No. 2 back.
Detroit Lions: Vinny Curry, DE, Marshall
Detroit loves to take the best player on their board, and that would likely be Vinny Curry in this scenario. However, Curry would also fill a need of sorts. The Lions have franchised Cliff Avril. They'll need some insurance just in case they can't keep him beyond 2012.
Atlanta Falcons: Kelechi Osemele, G, Iowa State
The Falcons have to make two upgrades to the offensive line (left tackle, right guard). They've shown a ton of interest in Kelechi Osemele.
Pittsburgh Steelers: Bobby Massie, OT, Ole Miss
Ben Roethlisberger is constantly knocked around, so the Steelers really need to make an effort to bolster the offensive front so he doesn't have to take as much punishment going forward. If he keeps taking nasty hits, his career will end much sooner than it should.
Denver Broncos: Brandon Thompson, DT, Clemson
The Broncos could easily go with two defensive tackles in the first couple of rounds. That's how desperate they are at the position. I wouldn't say they're locked into doing this, but Brandon Thompson is the top player available who makes sense for Denver.
Houston Texans: Mitchell Schwartz, OT, California
The Texans will start Rashad Butler at right tackle in the wake of Eric Winston's departure, but they'd be crazy not to find some competition for him.
Green Bay Packers: Derek Wolfe, DE/DT, Cincinnati
Green Bay could look at a five-tech early in the 2012 NFL Draft. Jarius Wynn isn't bad, but he's not very good either, while Mike Neal can't seem to stay healthy. Neal struggled since coming back anyway.
Baltimore Ravens: Mychal Kendricks, ILB, California
Ozzie Newsome indicated that he'll be looking for Ray Lewis' successor this upcoming April. Mychal Kendricks, the reigning Pac-12 Defensive Player of the Year, proved scouts wrong by showing off his unbelievable athleticism at the Combine.
Pick change; previously Mychal Kendricks, ILB
San Francisco 49ers: Brandon Boykin, CB, Georgia
The 49ers will want to spend a pick on a cornerback sometime in the middle rounds. Carlos Rogers turns 31 soon, while the newly signed Perrish Cox is a even bigger question mark. This is a bit earlier than "the middle rounds," but Brandon Boykin is one of the best players available.
New England Patriots: Zach Brown, LB, North Carolina
The Patriots are obviously expected to add a pass-rushing linebacker early in the 2012 NFL Draft. They're also seeking a smaller linebacker who can cover. Zach Brown was once considered a first-round prospect, so he offers tremendous value here.
New York Giants: Dwayne Allen, TE, Clemson
Jake Ballard was a decent tight end, but he tore his ACL. The Giants needed competition at the position anyway. They signed Martellus Bennett, but that was just to a 1-year deal.